Absorption and Distribution: Fenofibrate is well absorbed from the gastro-intestinal tract. Peak plasma levels of Fenofibric Acid occur within 6 to 8 hours after administration. The absorption of Fenofibrate is Increased when administered with food by approximately 35% In healthy volunteers, steady- state plasma levels of fanoflbric acid were shown to be achieved within 5 days of dosing. Serum protein binding was approximately 99% In normal end hyperlipidemic subjects.

Metabolism and Excretion: Following oral administration, Fenoflbrate is rapidly hydrolyzed by esterases to the active metabolite, Fenoflbric Acid; no unchanged Fenofibrate is detected in plasma. In vivo metabolism data indicate that neither Fenofibrale nor Fenoflbric Acid undergo oxidative metabolism (e.g., cytochrome P450) to a significant extent. After absorption, Fenoflbrate is mainly excreted in the urine In the fonn of metabolites, primarily Fenofibric Acid and Fenofibric Acid Glucuronide, after administration of radiolabelled Fenofibrate, approximately 60% of the dose appeared In the urine end 25% was excreted in the feces. The mean plasma half•life is 22.1 h (Range: 19.6-26.6 h)in healthy young adults, allowing once daily administration in a clinical setting.