Cosat is a preparation of co-trimoxazole, a chemotherapeutic agent effective against a wide range of Gram-positive and Gram-negative organisms.
 

Cosat is indicated in:
Respiratory tract infections : Acute and chronic bronchitis, bronchiectasis, lobar and broncho-pneumonia, otitis media and sinusitis .
Genito-urinary tract infections : Urethritis, cystitis, pyelonephritis, prostatitis, and gonorrhoea in penicillin allergic patients.
Gastrointestinal infections : Typhoid and paratyphoid fever, chronic carriage if Salmonella typhi and paratyphi, cholera and shigellosis.
Skin infections : Pyoderma, abscesses and wound infections .
Other bacterial infections : Acute and chronic osteomyelitis, acute brucellosis, septicaemia and other infections caused by sensitive pathogens.

Adults and children over 12 years : The usual daily dosage is 1 Cosat-DS tablet twice daily . 

For Severe infections : 1½ Cosat-DS tablets twice daily.

For long term treatment (more than 14 days) : ½ Cosat-DS tablet twice daily.

Prophylaxis of recurrent urinary tract infections : ½ Cosat-DS tablet at night. In gonorrhea, 2 Cosat-DS tablets twice daily for 2 days . Alternatively 2½ Cosat-DS tablets followed by a second dose at 8 hours interval.

Children 6-12 years : ½ Cosat -DS tablet twice daily or as directed by physician.

Cosat suspension :

Children :
6 weeks to 6 months : 2.5 ml (½ teaspoonful) twice daily.

6 months to 6 years : 5 ml (1 teaspoonful) twice daily .
6 -12 years : 10 ml (2 teaspoonful ) twice daily.
In acute infections, Cosat should be given for at least 5 days or until the patient has been symptom free for 2 days.
 

Cosat should not be given to patient with a history of hypersensitivity to sulphonamide, trimethoprim or co-trimoxazole. It is contraindicated in patients showing marked liver parenchymal damage and in severe renal insufficiency. It should not be given in pregnancy, in patients with serious haematological disorders and in infants under 6 weeks.
 

In prolonged treatment, complete blood count is to be performed at monthly intervals in renal impairment, a modified dosage schedule is indicated and adequate fluid intake is required. It is to be taken with caution during breast feeding. Treatment should be discontinued if skin rash appears.
 

Nausea, vomiting, skin rashes, glossitis can occur, Cosat may cause thrombocytopenia, purpura, leucopenia & very rarely agranulocytosis.
 

Store in a cool dry place, away from light. Keep out of the reach of children.
 

Cosat-DS tablet : Box contains 10 strips of 10 tablets. Each tablet contains 160 mg trimethoprim BP and 800 mg sulphamethoxazole BP.
Cosat suspension : 60 ml suspension in amber glass bottle with a measuring cup. Each 5 ml contains 40 mg trimethoprim BP and 200 mg sulphamethoxazole BP. 



Manufactured by:
ESKAYEF BANGLADESH LTD
DHAKA, BANGLADESH
® REGD.TRADEMARK