Carbolin^® is the preparation of carbocisteine. It reduces the viscosity of non-infected secretions from mucus cells in the respiratory tract. The mucolytic action is due to two mechanisms. It breaks the disulphide bonds which cross-link certain glycoprotein molecules present in the mucus and it also alters local ionic charges, both of which factors affect the viscosity of mucus. There is also evidence that it alters the composition of mucin secreted by the respiratory mucosa, decreasing the proportion of neutral glycopeptides and increasing the sialoglycopeptides.
 

1. Expectoration in the following diseases

• Upper respiratory tract inflammation (pharyngitis, laryngitis)
• Acute bronchitis
• Bronchial asthma
• Chronic bronchitis
• Bronchiectasis
• Pulmonary tuberculosis

2. Drainage in chronic sinusitis
3. Drainage in otitis media with effusion

Adults (including elderly): Dosage is based upon an initial dose of 2250 mg daily in divided doses (750 mg 3 times daily), reduced to 1500 mg daily in divided doses (375 mg 4 times daily), when a satisfactory response has been obtained.

Children: Normal daily dose is 20 mg/kg body weight in divided doses.
The following dosage is recommended:
2-5 years : 62.5-125 mg 4 times daily.
6-12 years : 250 mg 3 times daily.
Infants: Dosage in infants has not been established.
 

Gastrointestinal discomfort, nausea, diarrhoea, gastrointestinal bleeding, headeche and skin rash may occur.
 

No specific precaution is recommended but carbocisteine should be used with a caution in patients with a recent history of peptic ulcer and recurrent gastrointestinal bleeding.

Although there are no reports of teratogenic effects with carbocisteine, the drug is not recommended in the first trimester of pregnancy. No information available on the use of carbocisteine during lactation.
 

Contraindicated in active peptic ulceration and in patients with hypersensitivity to the drug. 

Store in a cool, dry place, away from light. Keep out of reach of children.
 

Carbolin^® capsule : Box containing 5 strips of 6 capsules each. Each capsule contains carbocisteine BP 375 mg.
Carbolin^® syrup : Bottle containing 100 ml syrup. Each 5 ml contains carbocisteine BP 125 mg.
Carbolin^® DS syrup : Bottle containing 100 ml syrup. Each 5 ml contains carbocisteine BP 250 mg.

 

Capsule manufactured by: ESKAYEF BANGLADESH LTD DHAKA, BANGLADESH ® REGD.TRADEMARK

Syrup and DS syrup manufactured by: ESKAYEF BANGLADESH LTD DHAKA, BANGLADESH ® REGD.TRADEMARK